Education 1996 – 2002 University of Bochum, Germany, Medical School 2002 Medical thesis
Professional Experience 2002-2004 Clinical research experience in the Neurogenetics group of Prof. Klein at the University of Lübeck 2004-2006 Neuroepidemiology Fellowship (Postdoctoral position) at the Parkinson’s Institute in Sunnyvale, California, USA June 2010 Start of the first independent research project funded by the German Research Foundation (KA 3179/2-1) 2014-2019 Interdisciplinary research project with clinical trial on mitochondrial impairment in Parkinson disease funded by the German Ministry and Education and Science (BMBF) 2014-2018 Collaborative research unit SFB134 “hedonic eating behaviour: homeostasis and reward” PI in cohort project 2016-2019 Research group “ProtectMove”, PI in cohort project (DFG FOR 2488) Since 2019 LRRK2recruitmentandcharacterizationprojecttogether with the biotechnology company Centogene in Rostock Since 2020 Second phase of “ProtectMove” (DFG FOR 2488)
After Medical School Prof. Kasten chose to pursue research and clinical education in parallel and started both in Lübeck, spent two years in California to learn Neuroepidemiology, and decided to focus on psychiatric signs, symptoms and diseases mainly in the overlap with neurological movement disorders.
Epidemiology of psychiatric symptoms and disorders in movement disorders and work focusing on harmonization of clinical data, building and characterization of cohorts including follow-up.
Kasten M, et al. (2013) Cohort Profile: A population-based cohort to study non-motor symptoms in parkinsonism (EPIPARK). Int J Epidemiology, 2013 Feb;42(1):
Tunc S, […], Kasten M. A population-based study on combined markers for early Parkinson’s disease. Mov Disord. 2015 Apr;30(4):531-7
Lawton M, Kasten M, et al. Validation of conversion between mini-mental state examination and montreal cognitive assessment. Mov Disord. 2016 Apr;31(4)
Kasten M, et al. MDSGene review of genotype-phenotype relations for the Parkinson’s disease genes Parkin, PINK1, DJ1. Mov Disord. 2018 May;33(5).
Vollstedt EJ, Kasten M, Klein C. MJFF Global Genetic Parkinson’s Disease Study Group. Using global team science to identify genetic Parkinson’s disease worldwide. Ann Neurol. 2019 Jun 2
Prof. Kasten has been and is active in several international consortia, e.g. the “Neurobiomedizin” effort funded twice by the Schleswig-Holstein research department, there she coordinated the grant and project completion. She served as PI in the CRS 134 in the central project, together with Prof. Krämer she built and tracked a cohort of 656 population derived participants. In “Protect Move” she serves in the central project, coordinating large parts of the clinical data with respect to data entry, quality control, harmonization, and distribution. In her own DFG funded study “EPIPARK” she also built a large cohort (currently ~1200 participants) that is now in the 9th re-examination. This cohort contributes to the research on early diagnosis of Parkinson disease.