Education 1990-97 University of Lübeck, Germany, Medical School 1998-2005 Clinical training in Internal Medicine, UKSH Lübeck 2004 Medical thesis 2007-08, 2012-13 Clinical training in Internal Medicine, UKSH Lübeck 2013 Board certification for Internal Medicine 2013-15 Specialist physician in the Department of Emergency Medicine, UKSH Lübeck 2015 Habilitation in Internal Medicine, University of Lübeck 2015-20 Clinical training in Rheumatology, UKSH Lübeck 04/2020 W2 Professorship for Psychoneuroimmunology, University of Lübeck
Professional Experience 2002-04 Member of the Research Group FOR456 on sleep and memory 2008-11 Group leader, Institute of Neuroendocrinology (Prof. Jan Born), University of Lübeck 2009-17 PI in the Collaborative Research Center (TR/)SFB654 ‘Plasticity & Sleep’ on sleep and immunological memory 2011-12 Habilitation grant of the University of Lübeck 2015-20 Group leader, Department of Rheumatology & Clinical Immunology (Prof. Gabriela Riemekasten) 2020-23 Co-PI in the BMBF funded consortium MESINFLAME on inflammatory musculoskeletal diseases
After Medical School Prof. Lange combined her clinical training in Internal Medicine with basic research on sleep-immune interactions in healthy individuals in the frame of DFG-funded interdisciplinary consortia on sleep and (immunological) memory formation. After her board certification and habilitation in Internal Medicine, she started her clinical training in Rheumatology, received a professorship for psychoneuroimmunology and currently delineates brain-immune interactions in patients with systemic autoimmune diseases.
Bidirectional interactions between the brain and the immune system in healthy volunteers and in patients with systemic autoimmune diseases with a focus on sleep, the circadian system, the stress axes (hypothalamus-pituitary-adrenal axis, sympathetic nervous system), inflammation and T-cell memory formation.
Besedovsky L, Lange T*, Haack M. The Sleep-Immune Crosstalk in Health and Disease. Physiol Rev. 2019 Jul 1;99(3):1325-1380 *corresponding author
Dimitrov S*, Lange T*, et al. Gαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells. J Exp Med. 2019 *contributed equally
Westermann J, Lange T, Textor J, Born J. System consolidation during sleep – a common principle underlying psychological and immunological memory formation. Trends Neurosci. 2015 Oct;38(10):585-597.
Lange T, Dimitrov S, Bollinger T, Diekelmann S, Born J. Sleep after vaccination boosts immunological memory. J Immunol. 2011 Jul 1;187(1):283-90.
Dimitrov S, Benedict C, Heutling D, Westermann J, Born J, Lange T. Cortisol and epinephrine control opposing circadian rhythms in T cell subsets. Blood. 009;113(21):5134-43.
Prof. Lange is experienced in interdisciplinary research linking psychology, neuroscience, immunology, rheumatology and endocrinology with strong national and international collaborations. She is member of the EXC PMI, the CBBM, and the ELISA study group. The Department of Rheumatology & Clinical Immunology with 4,000 outpatients and 1,000 inpatients per year performs in-depth immunological analyses in individuals with systemic autoimmune diseases. Monitoring of psychosocial aspects like stress, sleep and fatigue started in 2017 and first data analyses are ongoing.